细胞DNA倍体分析与常规细胞学诊断对宫颈上皮内瘤变诊断评估的比较

Comparative Analysis of Diagnosis and Evaluation of Cervical Epithelial Neoplasia by Cell DNA Double Body Analysis and Conventional Cytological Diagnosis

目的研究细胞DNA倍体分析与常规细胞学诊断对宫颈上皮内瘤变诊断评估效果。方法选取2016年3月—2017年3月期间来本院行细胞DNA倍体分析和常规细胞学诊断的140例患者,其中可疑阳性患者26例,所有患者全部进行病理组织检验,对比两组检验方法的灵敏性。结果本次研究的常规细胞学诊断灵敏度为:22.2%、特异性:75.0%,DNA倍体分析诊断的灵敏度:77.8%,特异性:91.7%,比较常规细胞学与DNA倍体分析的诊断灵敏度,对比数据差异性显著,统计学意义存在(χ2=5.5556,P<0.0184)。结论宫颈上皮内瘤变诊断中,DNA倍体分析的诊断灵敏度显著高于常规细胞学诊断,所以DNA倍体分析的诊断效果更好,不但可以应用在宫颈上皮内瘤变诊断中,还能够判断宫颈上皮内瘤变的发展趋势,值得临床广泛推广。

Objective To study the effect of cell DNA double body analysis and conventional cytology diagnosis on cervical intraepithelial neoplasia. Methods Forty patients with DNA doubling analysis and routine cytology diagnosed from March,2016 to March,2017 in our hospital were selected,including 26 suspicious positive patients and all the patients were pathologically tested,and compared with two test methods Sensitivity. Results The study of the sensitivity to conventional cytology diagnosis:22.2%,specificity:75.0%,DNA times body analysis,the sensitivity of diagnosis:77.8%,specificity:91.7%,comparing to conventional cytology and DNA times analysis. The diagnostic sensitivity of boundary of comparative data exist(χ~2=5.5556,P<0.0184). Conclusion In the diagnosis of cervical intraepithelial neoplasia,the diagnostic sensitivity of DNA ploidy analysis is significantly higher than conventional cytological diagnosis,so the DNA ploidy analysis of the diagnosis is better,not only can be used in the diagnosis of cervical intraepithelial neoplasia,but also to determine the development trend of cervix intraepithelial neoplasia. It is widely clinical promotion.