喹硫平与利培酮治疗精神分裂症的对比研究

A Comparative Study of Quetiapine and Risperidone in Treatment of Schizophrenia

目的比较喹硫平与利培酮治疗精神分裂症的临床效果。方法选取2016年8月—2017年8月本院收治的96例精神分裂症患者,按照数字表法随机分为利培酮组和喹硫平组,各48例,并比较两组患者临床疗效和安全性。结果利培酮组和喹硫平组的临床治疗总有效率无差异显著(77.1%vs.70.8%,P>0.05),利培酮组的临床痊愈率显著高喹硫平组(45.8%vs.20.8%,P<0.05);喹硫平组患者阴性症状评分、阳性症状评分、一般精神病理评分和PANSS评分均明显低于利培酮组(P<0.05);喹硫平组患者震颤、静坐不能发生率均明显低于利培酮组(P<0.05)。结论利培酮相与喹硫平在治疗精神分裂症方面疗效相近,但喹硫平的不良反应发生率更低。

Objective To compare the clinical effect of quetiapine and risperidone in the treatment of schizophrenia. Methods A total of 96 patients with schizophrenia admitted to our hospital from August 2016 to August 2017 were randomly divided into risperidone group and quetiapine group according to the digital table method,48 cases in each group. The clinical efficacy and safety were evaluated. Results The total effective rate of risperidone group and quetiapine group was no significant difference(77.1% vs. 70.8%,P>0.05),the clinical cure rate of risperidone group was significantly higher quetiapine group(45.8% vs. 20.8%,P<0.05). Negative symptom score,positive symptom score,general psychopathology score and PANSS score of quetiapine group were significantly lower than those of risperidone group(P<0.05);quetiapine The incidence of incapacity was significantly lower than that of risperidone group(P<0.05). Conclusion Risperidone and quetiapine have similar efficacy in the treatment of schizophrenia,but the incidence of adverse reactions are lower in quetiapine.