血管紧张素Ⅱ受体拮抗剂和雷公藤多甙对糖尿病肾病患者白蛋白和肾功能的影响

Effects of ARB and Tripterygium Wilfordii Polysaccharide on Albumin and Renal Function in Patients with Diabetic Nephrotic Disease

目的探讨血管紧张素Ⅱ受体拮抗剂(ARB)制剂联合雷公藤多甙对糖尿病肾病患者白蛋白和肾功能的影响。方法对照组采用ARB制剂缬沙坦联合常规治疗,观察组则在此基础上给予雷公藤多甙进行治疗。观察两组患者在治疗前,治疗后3个月、6个月的白蛋白和肾功能变化,同时比较两组治疗总有效率。结果观察组患者治疗总有效率为96.15%(75/78),对照组为74.36%(58/78),即明显观察组优于对照组,比较具有显著差异(P<0.05)。结论糖尿病肾病患者采用ARB制剂联合雷公藤多甙治疗效果显著,可明显提升患者白蛋白,同时不会对肾功能产生不良影响。

Objective To investigate the effect of ARB preparation combined with Tripterygium wilfordii polysaccharide on albumin and renal function in patients with diabetic nephropathy. Methods The control group was treated with ARB and valsartan combined with routine treatment,and the observation group was treated with Tripterygium wilfordii polysaccharide on this basis. The changes of albumin and renal function were observed in the two groups before treatment,3 months and 6 months after treatment,and the total effective rate in the two groups was compared. Results The total effective rate of observation group was 96.15%(75/78),the control group was 74.36%(58/78),which is obvious observation group than the control group,the difference was significant(P<0.05). Conclusion For patients with diabetic nephropathy,using ARB preparation combined with Tripterygium Wilfordii and significant therapeutic effect can significantly enhance the serum albumin,without adverse effects on renal function.