恶性肿瘤中自噬的信号衔接蛋白P62

Autophagy Signaling Adaptor Protein P62 in Malignant Tumors

衔接蛋白参与选择性自噬,并与细胞毒素降解和压力缓解密切相关。然而,最近研究发现衔接蛋白p62(由Sqstm1基因编码)在上皮组织中肿瘤形成和基质中肿瘤抑制起到独立于自噬的重要作用。

Adaptor proteins praticpate in selective attophagy,which is critical for cellular detoxification and stress relief.However,new evidence supports an autophagy-independent key role of the adaptor P62(encoded by the gene sqstm1)in signaling functions central to tumor initation in the epithelium and suppression of tumor progression int the stroma.