噻托溴铵治疗哮喘的疗效及自主神经功能变化分析

Effect of Tiotropium on Asthma and Changes of Autonomic Nerve Function

目的探讨噻托溴铵治疗哮喘的临床疗效和自主神经功能变化情况。方法选取2015年5月—2016年11月本院收治的哮喘患者100例作为本组的研究对象,并分别采用常规治疗(对照组)和在常规治疗基础上采用噻托溴铵粉吸入剂给予治疗(研究组),每组各50例。对两组患者的临床治疗效果及治疗前后的自主神经功能变化情况进行对比。结果研究组患者治疗总有效率94%明显高于对照组72%(P<0.05)。治疗后两组患者FVC、FEV1、FEV1%均明显优于治疗前,且研究组患者FVC、FEV1、FEV1%优于对照组(P<0.05)。结论在哮喘疾病治疗中采用噻托溴铵治疗,可以有效降低患者自主神经兴奋性,使患者临床症状得到改善。

Objective To investigate the clinical efficacy and autonomic nervous system function of tiotropium bromide in the treatment of asthma. Methods A total of 100 patients with asthma admitted to our hospital from May 2015 to November 2016 were selected as the study subjects and were treated with conventional treatment(control group)and tiotropium bromide inhalation on the basis of routine treatment Treatment(study group),50 patients in each group. The clinical efficacy of the two groups of patients before and after treatment and autonomic nervous system function changes were compared. Results The total effective rate of treatment in study group was significantly higher than that in control group(94%,P<0.05). After treatment,FVC,FEV1,FEV1% of two groups were significantly better than before treatment,and FVC,FEV1,FEV1% of the study group was better than the control group(P<0.05). Conclusion The treatment of asthma with tiotropium,can effectively reduce the excitability of patients with autonomic nervous system,so that patients with clinical symptoms improved.