HPV亚型感染地域分布与宫颈病变的关系

Relationship Between Geographic Distribution of HPV Subtype Infection and Cervical Lesions

目的分析人乳头瘤病毒(HPV)亚型感染的地域分布与宫颈病变的关系。方法回顾性分析874例患者,分样检测HPV,并进行HPV液基细胞学检测,HPV分型检测,若检测结果为阳性或者细胞学检查≥ASCU S,再予以阴道镜宫颈活性检测。结果 HPV分型检测发现397例呈阳性,检出率为45.42%(397/874)。宫颈病变中,最常见的类型包括58型、56型、52型、11型、16型号、18型及33型,其中,HPV16型与HPV58型检出率较高。结论分型检测HPV,可准确分析基因类型,联合液基细胞学检测,可高效检查宫颈病变组织,为尽早发现诊治宫颈癌,提供可靠依据。

Objective To analyze the relationship between the regional distribution of human papillomavirus(HPV)subtype infection and cervical lesions. Methods A retrospective analysis of 874 patients were conducted with sub-HPV testing and HPV liquid-based cytology,HPV genotyping test,if the test results were positive or cytology ≥ ASCU S,and then colposcopy cervical activity test. Results Totally 397 cases were positive by HPV typing test,with detection rate of 45.42%(397/874). The most common types of cervical lesions include type 58,type 56,type 52,type 11,type 16,type 18 and type 33. Among them,HPV16 type and HPV58 type detection rate is higher. Conclusion HPV genotyping can detect genotype accurately,combined with liquid-based cytology test can effectively check the cervical lesions for the early diagnosis and treatment of cervical cancer,provide a reliable basis.