原发性干燥综合征合并间质性肺疾病的回顾性分析

Retrospective Analysis of Primary Sjogren Syndrome with Interstitial Lung Disease

目的分析原发性干燥综合征(pSS)合并间质性肺疾病患者的临床特征。方法将107例pSS患者按是否合并肺间质病变分为肺间质病变(ILD)组39例,非肺间质病变组68例。分别对患者的基本资料、临床表现、实验室检验、影像学检查、肺功能测定及疗效进行回顾性分析。结果 ILD组年龄大于非肺间质病变组,ESR、CRP、免疫球蛋白和球蛋白水平均高于非肺间质病变组,差异有统计学意义(P<0.05)。ILD组患者肺高分辨率CT(HRCT)检查、肺功能检查均存在异常;所有患者均予糖皮质激素及环磷酰胺治疗3个月以上,29例患者的实验室指标、肺功能、临床症状都有一定改善,8例无明显改善,2例病情进展。结论对pSS早期诊断和早期规范治疗,有助于改善合并ILD患者的预后。

Objective To analyze the clinical features of primary dryness syndrome(p SS)in patients with interstitial lung disease. Methods Totally 107 patients with p SS were divided into 39 cases of pulmonary interstitial lesion and 68 cases of non-pulmonary interstitial lesion. The basic data,clinical manifestation,laboratory test,imaging examination,lung function measurement and curative effect were analyzed retrospectively. Results The age of the group was older than that of the non-pulmonary interstitial lesion group,and the levels of ESR,CRP,immunoglobulin and globulin were higher than those in the non-pulmonary interstitial lesion group,and the difference was statistically significant(P<0.05). Patients with high resolution CT and lung function examination were abnormal. All patient were treated with glucocorticoid and cyclophosphamide for more than 3 month,the laboratory indexes,pulmonary functions and clinical symptoms of 29 patient were improved,8 patients were not improved,2 patients were progressed. Conclusion The early diagnosis and early standard treatment of p SS can improve the prognosis of patients with complicated patients.