侵袭性肺部真菌感染的早期诊断

Early Diagnosis of Invasive Pulmonary Fungal Infection

目的研究血清与支气管肺泡灌洗液(BALF)联合葡聚糖检测对早期诊断侵袭性肺部真菌感染(IPFI)的临床价值。方法选取2015年4月至2017年8月侵袭性肺部感染患者80例,其中40例真菌感染患者,为观察组,剩余的40例细菌感染患者为对照组,这些患者均接受血清与BALF联合葡聚糖检测。结果观察组患者血浆中的G试验水平以及BALF的G试验水平显著高于对照组,其中血浆中G试验检测特异性更为显著(P<0.05)。结论血清以及BALF的G试验检测应用到IPFI患者的病情诊断中均具有显著的价值,其中血浆G试验检测的特异性更为显著,联合使用两种检测方法能够更准确的准断患者的病情,临床应用价值显著。

Objective To study the clinical value of combined detection of serum and bronchoalveolar lavage fluid(BALF)combined with dextran in the early diagnosis of invasive pulmonary fungal infection(IPFI). MethodsEighty patients with invasive pulmonary infection from April 2015 to August 2017 were divided into observation group(40 patients with fungal infection)and control group(40 patients with bacterial infection). All patients were examined with serum and BALF combined with dextran. Results The plasma G level and BALF G test level in the observation group were significantly higher than those in the control group,especially in plasma G test. Conclusion Serum BALF and G test applied to the significant value of diagnosis in patients with IPFI,including specific plasma G test is more significant,the combined use of the two detection methods can more accurate diagnosis of the patient has significant clinical application value.