盐酸氨溴索与抗生素联合治疗慢性支气管炎的效果分析

Analysis of Effect of Ambroxol Hydrochloride Combined with Antibiotics on Chronic Bronchitis

目的探讨盐酸氨溴索与抗生素联合治疗慢性支气管炎的效果分析。方法选取2017年2月至2018年2月本院呼吸内科收治的140例慢性支气管炎患者随机分为两组,对照组采用盐酸氨溴索治疗,观察组采用盐酸氨溴索与莫西沙星联合治疗,比较两组患者的临床疗效、症状消退时间、炎性介质水平(IL-6、IL-8、TNF-α)。结果观察组治疗有效率为95.7%,显著高于对照组的78.6%(P<0.05);观察组治疗后咳嗽、气喘、咳痰、肺部湿罗音等症状消失时间显著短于对照组(P<0.05);观察组治疗后血清IL-6、IL-8、TNF-α水平与对照组比较,差异有统计学意义(P<0.05)。结论盐酸氨溴索与抗生素联合治疗慢性支气管炎的效果显著,能有效抑制炎症,促进呼吸道症状的快速改善,提升临床疗效。

Objective To investigate the effect of ambroxol hydrochloride combined with antibiotics in the treatment of chronic bronchitis. Methods A total of 140 patients with chronic bronchitis from February 2017 to February 2018 were randomly divided into two groups. The control group was treated with ambroxof hydrochloride and the observation group was treated with berberine on the basis of the control group. The clinical therapeutic effect,symptom disappear time and serum levels of interleukin (IL-6, IL-8,TNF-α) of the two groups were observed. Results The effective rate of the observation group was 95.7%, significantly higher than that in the control group was 78.6%(P<0.05). After treatment, the symptoms of cough, asthma, phlegm and lung hygrotone were significantly shorter than those in the control group(P<0.05). After treatment, serum IL-6, IL-8 and TNF-α were significantly lower than those in the control group(P<0.05). Conclusion Ambroxol hydrochloride combined with antibiotics has significant effects on chronic bronchitis, which can effectively inhibit inflammation, promote rapid improvement of respiratory symptoms, and improve clinical efficacy.