大剂量氨溴索治疗重症肺炎的疗效

Effect of Large Dose Ambroxol in the Treatment of Severe Pneumonia

目的探讨大剂量氨溴索治疗重症肺炎疗效及安全性。方法选取74例重症肺炎患者,分为对照组和观察组,各37例。对照组予以集束化治疗,观察组在集束化治疗基础上加用大剂量氨溴索治疗,2周后分析对比两组临床总有效率、炎性指标水平(血清降钙素原、C反应蛋白)、血气分析指标(氧分压、氧合指数、动脉血氧饱和度)及不良反应发生率。结果观察组患者的临床总有效率显著高于对照组,炎性指标水平显著低于对照组(P<0.05)。观察组氧分压显著低于对照组,氧合指数及动脉血氧饱和度显著高于对照组(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论大剂量氨溴索治疗重症肺炎可有效改善患者预后。

Objective To explore the efficacy and safety of high dose ambroxol in the treatment of severe pneumonia. Methods Seventy-four patients with severe pneumonia were divided into control group and observation group(37 cases each). The control group was treated with cluster therapy,and the observation group was treated with high dose ambroxol on the basis of cluster therapy. After 2 weeks,the total clinical effective rate,inflammatory index(serum procalcitonin,C-reactive protein),blood gas analysis index(oxygen partial pressure,oxygenation index,arterial oxygen saturation)and adverse reaction rate were compared. Results The total clinical effective rate of the observation group was higher than the control group,while the inflammatory index level was lower than the control group(P<0.05). The blood gas analysis indexes in the two groups were different(P<0.05),the partial pressure of oxygen in the observation group was lower than the control group,while the oxygenation index and arterial oxygen saturation were higher in the observation group(P<0.05). The incidence of adverse reactions between the two groups have no statistical significance(P>0.05).ConclusionTreatment of severe pneumonia with high dose ambroxol could improve the prognosis of patients.