埃索美拉唑治疗反流性食管炎的临床疗效

Clinical Efficacy of Esomeprazole in Treatment of Reflux Esophagitis

目的观察埃索美拉唑治疗反流性食管炎的临床疗效。方法选取2016年3月至2017年3月本院收治的126例反流性食管炎患者,随机分为对照组和观察组,各63例。对照组采用奥美拉唑治疗,观察组采用埃索美拉唑治疗,比较两组症状积分改善情况、食管炎愈合情况以及不良反应发生情况。结果治疗后,两组症状积分均显著低于治疗前,其中观察组显著优于对照组(P<0.05);观察组胃镜下食管炎愈合总有效率显著高于对照组(P<0.05);观察组不良反应发生率显著低于对照组(P<0.05)。结论埃索美拉唑治疗反流性食管炎可快速缓解患者临床症状缓解其痛苦,不良反应少,用药安全性较高。

Objective To observe the clinical efficacy of esomeprazole in treatment of reflux esophagitis. Methods From March 2016 to March 2017,126 patients with reflux esophagitis were randomly divided into control group and observation group,63 cases each. The control group was treated with omeprazole,and the observation group was treated with esomeprazole. The improvement of symptom scores,the healing of esophagitis and the occurrence of adverse reactions were compared between the two groups. Results After treatment,the symptom scores in both groups were significantly lower than those before treatment,and the observation group was significantly better than the control group(P<0.05). The total effective rate of esophagitis under gastroscope in observation group was significantly higher than that in control group(P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05). ConclusionEsomeprazole can quickly relieve the clinical symptoms of reflux esophagitis and relieve its pain,less adverse reaction and higher safety of medication.