血浆置换治疗重型肝炎的临床疗效

Effect of Plasmapheresis in Treatment of Severe Hepatitis

目的探讨血浆置换治疗重型肝炎的临床价值。方法选取2016年6月至2017年5月本院收治的90例重型肝炎患者,根据治疗方法分为对照组(给予单一常规内科方案治疗)和观察组(给予常规内科方案联合血浆置换治疗)。比较两组重型肝炎临床疗效;治疗前后IL-6、TNF-α、PTA;治疗前后患者肝功能情况。结果观察组重型肝炎临床疗效显著高于对照组(P<0.05);治疗前两组IL-6、TNF-α、PTA比较差异无统计学意义(P>0.05);观察组治疗后IL-6、TNF-α、PTA显著优于对照组(P<0.05);治疗前两组肝功能情况比较差异无统计学意义(P>0.05);治疗后观察组肝功能情况显著优于对照组(P<0.05)。结论常规内科方案联合血浆置换治疗重型肝炎的应用效果确切,可有效改善肝功能和降低炎症指标,提高PTA。

Objective To observe the clinical effect of plasmapheresis in the treatment of severe hepatitis. Methods Ninety cases with severe hepatitis from June 2016 to May 2017 were divided according to the treatment Methods. The control group was given conventional internal medicine treatment,and the observation group was given plasmapheresis on the basis of the control group. The clinical effect and IL-6,TNF-α,PTA,liver function before and after treatment between the two groups were compared. Results Clinical effect of severe hepatitis in the observation group was higher than that in the control group(P<0.05);before treatment,IL-6,TNF-α,PTA of the two groups were similar(P>0.05);after treatment,IL-6,TNF-α,PTA of the observation group were better than those of the control group(P<0.05);liver function condition of the two groups were similar before treatment(P>0.05);after treatment,liver function of the observation group was better than that of the control group(P<0.05). Conclusion Conventional internal medicine treatment combined with plasmapheresis in the treatment of severe hepatitis have a definite application effect,it can effectively improve the liver function and reduce inflammation indexes and PTA.