院前使用氨甲环酸对创伤性颅脑损伤患者死亡率和血管栓塞性并发症的影响

Effect of Pre-Hospital Administration of Aminocyclic Acid on Mortality and Vascular Embolism Complications in Patients with Traumatic Craniocerebral Injury

目的研究院前使用氨甲环酸对创伤性颅脑损伤患者死亡率和血管栓塞性并发症的影响。方法选取本院收治的180例创伤性损脑损伤患者作为研究对象,按照院前是否使用氨甲环酸进行救治分为两组,各90例。对照组入院后使用氨甲环酸治疗,观察组入院前使用氨甲环酸治疗,比较分析两组患者的死亡率、血管栓塞并发症的发生率、弥散性血管内凝血(DIC)评分、格拉斯哥预后评分(GOS评分)的改善情况。结果治疗前,两组患者的DIC、GOS评分比较,差异无统计学意义(P>0.05)。治疗后,观察组DIC评分显著低于对照组(P<0.05),观察组GOS评分显著高于对照组(P<0.05)。观察组死亡率、血管栓塞性并发症发生率为(6.67%,12.22%)与对照组(7.78%,13.33%)比较,差异无统计学意义(P>0.05)。结论在对创伤性颅脑损伤患者进行急救时,院前使用氨甲环酸对患者进行急救治疗能够获得更好的急救效果,患者的DIC评分能够得到显著改善,GOS评分显著提,改善患者的预后。

Objective To study the effect of aminocyclic acid on mortality and vascular embolism complications in patients with traumatic craniocerebral injury.Methods A total of 180 patients who received emergency treatment of traumatic brain injury in our first aid center were divided into two groups according to whether the patients were treated with tranexamic acid or not.90 patients in the control group were treated with tranexamic acid after admission.The mortality,incidence of vascular embolism complications,disseminated intravascular coagulation(DIC)score,and Glasgow outcome score(GOS)were compared between the two groups before admission to hospital.Results There was no significant difference in DIC and GOS scores between the two groups before treatment(P>0.05).After treatment,DIC score in the observation group was significantly lower than that in the control group(P<0.05),and GOS score was significantly higher than that in the control group(P<0.05).The mortality rate of patients in the observation group was 6.67%,the incidence of vascular embolism complications was 12.22%,the mortality rate of patients in the control group was 7.78% and the incidence of vascular embolism complications was 13.33%,without significant difference(P>0.05).Conclusion In the first aid of patients with traumatic brain injury,administration of tranexamic acid before hospital can obtain better first aid effect,increased the DIC and GOS scores of patients can be significantly improved,and greatly improved the prognosis of patients.