丙戊酸钠缓释片联合拉莫三嗪片治疗癫痫的临床疗效

Effect of Sodium Valproate Sustained Release Tablets Combined with Lamotrigine Tablets on Epilepsy

目的分析本院神经内科癫痫病的临床诊断及治疗效果。方法选取本院精神内科收治的106例癫痫病患者作为研究对象,随机分为对照组和实验组,各53例。对照组患者均采用丙戊酸钠缓释片进行治疗,实验组患者采取丙戊酸钠缓释片与拉莫三嗪片联合治疗的方法,经过4个月治疗后,比较两组治疗效果。结果对照组疗效显著22例,有效21例,无效10例,治疗有效率为81.13%。实验组疗效显著29例,有效21例,无效3例,治疗有效率为94.34%,实验组显著高于对照组(P <0.05)。对照组药物产生不良反应为18.87%,实验组对药物产生不良反应为5.66%,实验组显著低于对照组(P <0.05)。结论丙戊酸钠缓释片联合拉莫三嗪片可有效缓解癫痫患者症状,提高治疗疗效。

Objective To analyze the clinical diagnosis and therapeutic effect of epilepsy in department of neurology in our hospital. Methods A total of 106 patients with epilepsy were randomly divided into control group and experimental group,each 53 cases. The patients in the control group were treated with sodium valproate sustained-release tablets. The patients in the experimental group were treated with sodium valproate sustainedrelease tablets and lamotrigine tablets. After 4 months of treatment,the therapeutic effects of the two groups were compared. Results In the control group,22 cases were effective,21 cases were effective and 10 cases were ineffective. The effective rate was 81.13%. The effective rate of the experimental group was 94.34%,the effective case was 21,the ineffective case was 3,the experimental group was significantly higher than the control group(P<0.05). The ADRs of the control group and the experimental group were 18.87% and 5.66%,respectively. The ADRs of the experimental group were significantly lower than those of the control group(P<0.05). Conclusion Sodium valproate sustained-release tablets combined with lamotrigine tablets can effectively relieve the symptoms of epileptic patients and improve the therapeutic effect.