TH细胞因子与VEGF联合检测在非小细胞肺癌患者中的临床意义

Clinical Significance of Combined Detection of Serum TH Cytokines and VEGF Levels in NSCLC Patients

目的分析联合检测血TH细胞因子和VEGF水平在非小细胞肺癌(NSCLC)患者中临床意义。方法选取2016年5月至2018年5月在本院进行诊治的NSCLC患者40例(A组),肺部良性病变30例(B组),健康体检者32例(C组)。运用ELISA法检测3组的血清细胞因子IL-12、IFN-γ、IL-10、IL-6及VEFG,对比3组检测结果。结果 TH细胞因子浓度3组间均有显著性差异(P <0.05),VEGF在A与B、C组差异均有统计学意义;NSCLC患者血清TH细胞因子水平与与肿瘤大小、进展、转移等相关,随TNM的分期呈显著性升高(P <0.05)。结论 TH1/TH2细胞因子水平测定为NSCLC诊治提供免疫学依据,联合VEGF检测有助于临床判断TNM分期。

Objective To analyze the clinical significance of combined detection of serum TH cytokines and vascular endothelial growth factor(VEGF)levels in patients with non-small cell lung cancer(NSCLC).Methods From May 2016 to May 2018,40 NSCLC patients(Group A),30 benign pulmonary lesions(Group B)and 32 healthy subjects(Group C)were selected. Serum cytokines IL-12,IFN-γ,IL-10,IL-6 and VEFG were detected by ELISA and compared among three groups. Results There were significant differences in TH cytokine concentration between the three groups(P<0.05),and there were significant differences in VEGF of group A,as compared with group B and C. Serum TH cytokines levels were correlated with tumor size,progression and metastasis in NSCLC patients,and increased with TNM stage(P <0.05). Conclusion The level of TH1/TH2 cytokines can provide the immunological basis for the diagnosis and treatment of NSCLC. The combined detection of VEGF is helpful to the clinical judgment of TNM staging.