喹诺酮类抗菌药物的不良反应与临床合理应用

Adverse Reactions of Quinolones and Suggestions For Clinical Rational Use

目的探讨喹诺酮类抗菌药物的各种不良反应与临床合理应用建议。方法选取2017年2月至2018年3月本院收治的采用喹诺酮类抗菌药物进行治疗的200例患者作为研究对象,随机分为实验组和常规组,各100例。随机分组后常规组不采取任何干预措施,实验组落实临床建议,探讨不良反应发生率。结果实验组不良反应发生率(7.00%)明显优于常规组(20.00%),统计学结果有意义(P <0.05)。结论严格掌握禁忌症与适应症,按照抗菌谱与肝肾功能等明确疗程,可降低喹诺酮类抗菌药物的不良反应发生率与毒性,提高临床疗效。

Objective To explore the adverse reactions and clinical suggestions for the rational use of quinolones.Methods From February 2017 to March 2018,200 patients treated with quinolone antibacterial agents in our hospital were selected as study subjects,and randomly divided into experimental group and conventional group,100 cases each. The routine group did not take any intervention after random group. The experimental group carried out clinical recommendations and explored the incidence of adverse reactions. Results The incidence of adverse reactions(7.00%)in the experimental group was significantly better than that in the conventional group(20.00%),and the statistical results were significant(P<0.05). Conclusion Strict control of contraindications and indications,specific dose and treatment in accordance with antimicrobial spectrum and liver and kidney function,reduce the incidence of adverse reactions and toxicity,and improve the clinical efficacy.