血栓弹力图指导阿司匹林临床应用的回顾性研究

Retrospective Study on Clinical Application of Aspirin Guided by Thrombolytic Elasticity Map

目的采用血栓弹力图(TEG)的方法观察患者服用阿司匹林后的抑制率变化和相关因素分析。方法选取青岛大学附属青岛市市立医院门诊和住院部收治的42例中老年脑卒患者服用阿司匹林治疗为阿司匹林组;另选取未服用抗血小板药物的23例患者为对照组,检测两组患者的血栓弹力图测得凝血功能和AA途径诱导的血小板抑制率,并进行比较。结果 42例患者中,AA途径诱导的血小板抑制率阿司匹林组为86.61±24.87%,对照组为13.63±8.10%,阿司匹林组明显高于对照组(P <0.05)。结论血栓弹力图测定对临床阿司匹林应用具有指导作用。

Objective To observe the change of inhibition rate and related factors of aspirin use in patients in our hospital by thrombolytic elasticity chart(TEG).Methods Selection of Qingdao municipal hospital affiliated to Qingdao university outpatient and the inpatient of 42 cases of senile patients with brain death as the research object,taking aspirin treatment,as aspirin group,the other choice is not taking antiplatelet drugs in patients with 23 cases as control group,the test of two groups of patients with thrombus elastic figure measured blood coagulation function and the platelet inhibition rate induced by AA approach,and the comparison.Results In 42 patients,the platelet inhibition rate induced by AA pathway was 86.61%±24.87%in aspirin group and 13.63%±8.10%in control group,which was significantly higher than that in control group(P<0.05).Conclusion The determination of thromboelastography is helpful to the clinical application of aspirin.