精神科门诊患者使用苯二氮(卓)类药物情况调查

Investigation on Use of Benzodiazepine in Outpatient Department of Psychiatry

目的调查本研究所精神科门诊患者苯二氮卓类(BZDs)药物的使用情况,并对不合理的地方提出相应的改进措施。方法选取2016年至2017年12月本研究所精神科门诊患者1 500例为研究对象,从中筛选出使用BZDs的患者1 088例,对1 088例患者的用药种类、剂量、时间等情况进行分析。结果 BZDs种类中使用频率最高的是阿普唑仑,另外依次为氯硝西泮、地西泮,尚未发现超剂量用药。但BZDs药物的使用时间较长,平均超过4个月。单独使用BZDs发生药物依赖的患者共132例,依赖率12.13%,单独使用阿普唑仑、氯硝西泮、地西泮的患者在用药时间和用药剂量上较高的易发生依赖(P=0.00),单独使用硝西泮的患者在用药时间上较高的易发生依赖,差异有统计学意义(P=0.00)。结论本院精神科门诊患者BZDs药物的使用时间过长易成瘾,需加强BZDs的正确使用与管理,防止患者产生药物依赖。

Objective To investigate the use of benzodiazepine(BZDs)drugs in outpatients of the department of psychiatry of our hospital,and to propose corresponding improvement measures for unreasonable places.Methods Totally 1 500 cases of outpatients in the department of psychiatry of our hospital from January 2016 to December2017 were selected as the research objects,1 088 cases of patients using BZDs were screened out,and the drug types,dosage,time and other conditions of 1 088 cases of patients were analyzed.Results Alprazolam and clonazepam and diazepam were the most frequently used in BZDs.No overdose drugs were found.However,the use of BZDs was longer,averaging more than 4 months.The drug dependence rate was 12.13%in 132 patients with BZDs alone.Alprazolam and clonazepam were used alone.Patients with diazepam were more likely to be dependent on the time and dosage of diazepam(P=0.00),while patients with diazepam alone were more likely to be dependent on the time of administration(P=0.00),with statistical significance.Conclusion The use of BZDs in psychiatric outpatients in our hospital is easy to be addictive,so it is necessary to strengthen the correct use and management of BZDs so as to prevent patients from drug dependence.