皮肤源性前体细胞的研究进展

Research progress of skin-derived precursor cells

皮肤源性前体细胞(SKPs)是一种能从胚胎及成年真皮中提取的神经嵴来源的新的前体细胞,因其具有来源丰富、易于获取、具有多向分化潜能、无伦理限制等优点,在疾病治疗等方面均具有重要的研究意义和良好的应用前景。本文就SKPs的来源、定位、增殖与分化等对其研究进展作一综述。SKPs来源于胚胎神经嵴,但不同部位的SKPs来源亦略有不同。SKPs广泛存在于皮肤真皮中,DP是SKPs的一个富集龛,真皮层内的毛细血管周即是SKPs的另一富集龛,但关于SKPs体内富集龛位置的确定,仍需进一步的探索。SKPs可行自体移植并具有多向分化潜能,在机体多种组织修复和疾病治疗中有着重要的研究价值。

As a novel population of neural crest-origin precursor cells,skin-derived precursor cells(SKPs) can be isolated from both embryonic and adult dermis. These cells have important values for research and potential clinical application in wound healing,organ regeneration and disease treatment for advantages in the abundance of cell sources,accessibility,potential of multipotent differentiation,and absence of ethical concerns. Here we review the developmental and anatomical origins of SKPs and their potential application in regenerative medicine. SKPs originate from the embryonic neural crest,and their sources may vary in different areas of the body. SKPs are widely found in the dermis,especially in the dermal papilla(DP),which was known as a niche of SKPs. The multipotent SKPs can used for autologous transplantation and are of vital importance in tissue repair.