呼吸衰竭死亡新生儿肺血管疾病的临床病理分析:附38例报告

Clinicopathological analysis of pulmonary vascular disease in 38 neonates died of respiratory failure

回顾性分析38例呼吸衰竭死亡新生儿病例,取尸解肺组织石蜡切片,进行HE染色,部分以SP法行CD34、CD68、CK,TTF-1免疫标记和六胺银特殊染色,光学显微镜下观察肺血管发育情况、查找肺血管疾病。在这38例因呼吸衰竭死亡新生儿中,存在肺血管疾病5例,其中高血压性肺血管重塑3例,肺泡毛细血管发育不良2例。认为血管疾病是导致新生儿呼吸衰竭死亡的重要原因之一。

We reviewed the data of 38 neonates who died of respiratory failure.Paraffin sections of the autopsy lung samples were examined with HE staining or immunolabeling for CD34,CD68 and CK to observe the development of the pulmonary vessels and detect potential pulmonary vascular diseases(PVDs).Five cases were identified to have PVDs,including pulmonary hypertensive vascular remodeling in 3 cases and alveolar capillary dysplasia in 2 cases.The result indicated that PVD was one of the important reasons for respiratory failure in these neonates.