血浆干扰素诱导蛋白10在不同受累范围肺结核患者血浆中的表达

Plasma levels of interferon-inducible protein 10 in patients with active pulmonary tuberculosis with different affected areas

目的探讨干扰素诱导蛋白10(IP-10)在活动性肺结核辅助诊断及判断病情严重程度方面的参考价值。方法选择本院2013年2月～2017年2月健康体检者84例为对照组及住院肺结核患者193例为结核组,应用液相芯片Luminex技术检测观察对象血浆中IFN-γ和IP-10细胞因子的表达量。将结核组根据病灶范围所占面积可继续分为A组(1～2个肺野)、B组(3～4个肺野)和C组(5～6个肺野),比较3组患者IFN-γ和IP-10的表达差异。结果结核组患者血浆中IP-10的表达高于对照组,差异有统计学意义(P<0.05),而两组间IFN-γ的差异无统计学意义(P>0.05);IP-10在C组明显随病灶增多而升高,与其他组的差异有统计学意义(P<0.05),而IFN-γ在各组之间差异无统计学意义(P>0.05)。结论血浆IP-10对活动性肺结核的辅助诊断及病情严重程度的判断方面是具有一定的参考价值。

Objective To explore the value of interferon-inducible protein 10(IP-10)in the auxiliary diagnosis of tuberculosis and the judgment of the severity of disease.Methods From February,2013 to February,2017,a total of 193 patients with TB admitted in our hospital and 84 healthy control subjects were recruited consecutively.The peripheral blood plasma levels of interferon-γ(IFN-γ)and IP-10 were detected using liquid phase chip(Luminex)technique.According to the number of lung fields affected by TB,the patients were divided into group A(with lesions in 1-2 lung fields),group B(3-4 lung fields)and group C(5-6 lung fields),The expressions of IFN-γand IP-10 in 3 groups were compared.Results The plasma levels of IP-10 were significantly higher in TB patients than in the control subjects(P<0.05),but IFN-γlevels were comparable between the two groups(P>0.05).Among the TB patients,plasma IP-10 levels was the highest in group C(P<0.05),and IFN-γlevels did not differ significantly among the 3 groups(P>0.05).Conclusion Plasma IP-10 has a certain reference value in the auxiliary diagnosis of active tuberculosis and the judgment of the severity of the disease.