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苯并咪唑-5,6-二羧酸的合成 被引量:2

Studies for the Synthesis of Benzimidazole-5,6-dicarboxylic acid
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摘要 设计了苯并咪唑 5 ,6 二羧酸的新合成路线 ;解决了已有方法中的原料来源少 ,价格高 ,且含有微量重金属离子等问题 ;实现了苯并咪唑 5 ,6 二羧酸由常用原料、普通试剂和通用方法的简便合成 ,得到了可满足医药工业要求的产品 .该路线以苯酐为起始原料 ,经氨解、硝化、还原、重氮化氯代、硝化、氨解、还原、环合、水解九步 ,得到苯并咪唑 5 ,6 二羧酸 .总收率达 9.7% . This thesis developed a new method to prepare benzimidazole-5, 6-dicarbo-xylic acid. This method is low-priced and convenient. The product with no heavy metal ion can be used in pharmaceutical industry. Benzimidazole-5,6-dicarboxylic acid was prepared from phthalic anhydride by nine steps, which are amination, nitration, reduction, diazotisation, chlorination, nitration, amination, reduction, cyclization and hydration. The overall yield is 9.7%.
出处 《天津大学学报(自然科学与工程技术版)》 EI CAS CSCD 北大核心 2002年第5期652-654,共3页 Journal of Tianjin University:Science and Technology
关键词 苯并咪唑-5 6-二羧酸 医药中间体 合成 医药工业 苯酐 氨解反应 硝化反应 还原反应 Benzimidazole-5,6-dicarboxylic acid Medical intermediate Preparation
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同被引文献13

  • 1李倩.[D].天津大学,2002.
  • 2李倩.[D].天津大学,2002.
  • 3Koh J S,Kim j P. Synthesis of phthalimide-based alkali-dischargeable azo disperse dyes and analysis of their alkali-hydrolysis mechanism. Dyes & Pig, 1998,37 (3): 265-- 272.
  • 4Hiyoyuki M,Asuka O,Akihiko A,et al. Tumor necrosis factor-alpha production-inhibiting activity of phthalimlde analogues on human leukemia THP-1 cells and a structure-acti vity relationship study. Bioorg & Med Chem, 1997,5(11):2095--2102.
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  • 7M Hiyoyuki,O Asuka,A Akihiko,H Yuichi.Tumor necrosis factor -alpha production -inhibiting activith of phthalimide analogues on human leukeia THP-1 cells and a structure-activity relationship study [J].Bioorg &Med Chem.1997,5(11),2095-2102.
  • 8G Saroja ,A Samanta .Photophysical studies on a fluorescence prohe lahelled fatty acid :chain folding in a micellar environment [J].J Chem Soc ,Faraday Tran ,1996,92(15),2697-2701.
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  • 10黄爱聪,徐凤波,汪清民,曾强.O-[2-(取代)邻苯二甲酰亚胺基]乙基硫代磷酸脂的合成[J].化学工业与工程,1998,15(4):11-16. 被引量:3

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