二羧乙基锗倍半氧化物对大白鼠的致畸试验

Teratogenic Test of Carboxyethyl Germanium Sesquioxide in Rats

本文观察了二羧乙基锗倍半氧化物(carboxyethyl germanium sesquioxide,CEG)对三代大白鼠生殖的影响.从受孕第7天开始每天连续给药(2.5g/kg 或1.4g/kg)到受孕第15天为止,亲代孕鼠于第20天解剖,结果表明:给药组吸收胎率略高于对照组,但无统计学差异(P>0.05);活胎无外观或骨骼畸形,亲代交配生殖第二、第三代也未见异常.这说明 CEG 不影响胎鼠的生长发育.

The effcts of carboxyethyl germanium sesquioxide (CEG) on the reprodution of three generations of rats were observed.After intravenous injection of CEG in the dose of 2.5g/kg and 1.4g/kg daily from the 7th day of pregnancy to the 15th day,parental pregnant rats were autopsied on the 20th day of gestation.There was no significant difference in the resorption of fetuses in the three groups (P<0.05), indicatfng that CEG did not affect the growth of rat fetuses.Parental rats were paired to provide two and three-generation fetuses for examination,but neither external nor skeletal dysmor phosis in live futuses was found.