3-甲基犬尿喹啉酸衍生物的合成

Synthesis of 3-Methylkynurenic Acid Derivatives

报道了六个具有潜在生物活性 3 甲基犬尿喹啉酸衍生物的合成 .它们以取代苯胺和 3 甲基 2 酮丁二酸二乙酯为起始原料 ,经加成脱水 ,环化而得到 .其中三个新的含氟化合物的结构分别经IR ,1 HNMR ,MS 。

Six derivatives of 3 methylquinoline acids having latency biological activity were synthesized by addition of substituted anilines to ethyl ethoxalylpropionate and followed by high temperature cyclization. Among them, three new compounds containing fluorine were identified through elemental analyses, 1H NMR, IR and MS spectra.