nm^(23)基因产物/NDPK在喉癌中表达的意义

nm^(23) gene product/NDPK expression and its significance in laryngeal squamous cell carcinoma

目的研究nm^(23)基因产物/NDPK在喉癌中表达的临床意义。方法行全喉切除术的94例喉鳞状细胞癌的石蜡标本,采用抗nm^(23)-H1基因产物╱NDPK单克隆抗体进行免疫组织化学ABC法染色。结果 nm^(23)/NDPK在喉鳞状细胞癌中的阳性率为45.7%(43/94),nm^(23)╱NDPK在喉癌伴颈淋巴结转移和无颈淋巴结转移组织中的阳性率分别为33.3%(14/42)和55.8%(29/52),经卡方检验,P<0.05,两组间nm^(23)/NDPK阳性率存在显著性差异。结论结合临床和病理资料进行分析,结果显示nm^(23)/NDPK表达与喉癌分期、细胞的病理分级、肿瘤大小和术后3年生存率均无关;与喉癌颈淋巴结转移呈负相关,对预测喉癌颈淋巴结转移有一定的参考价值。

PURPOSE To examine the expression of nm23 gene product/ NDPK in laryngeal squamous cell carcinoma and to correlate nm23 gene product / NDPK expression with metastasis.METHODS Paraffin-embedded squamous cell carcinoma specimens from 94 patients who underwent laryngectomy were examined immunohistochemically. RESULTS 43(45.7%) of 94 laryngeal squamous cell carcinomas expressed nm23 /NDPK; Expression of nm23/NDPK was detected in 33.3%(14/42) and 55.8%(29/ 52)of cases with and without cervical lymph node metastasis respectively(P&lt;0.05).CONCLUSIONS Compared with clinicpathological feature, nm23/NDPK expression was not associated with stage, histologic grade,size,age,and postoperative 3 years survical rates. An inverse correlation was observed between nm23/ NDPK expression and lymph node metastasis. Our results indicate that nm23/NDPK may as a valuable marker for lymph node metastasis of laryngeal squamous cell carcinoma.