喉癌患者血清微量元素的研究

Study on serum trace elements of laryngeal cancer patients

目的探讨微量元素和喉癌的关系。方法对19例喉癌患者和19例其他患者血清中17种元素含量作了比较研究,其中硒检测采用荧光分光法,另外16种采用电感耦合等离子体源发射光谱法。结果通过探讨t检验发现喉癌患者硼、镉、钼、锌、磷、钛含量显著高于对照组,应用多元逐步回归分析发现镉、锌与喉癌关系最大。结论提示有必要对镉、锌含量与喉癌发生发展关系进行深入研究。

PURPOSE Aining at probing the relationship between trace elements and laryngeal Cancer to get some causation of cancer.METHODS We carried out a dompara-tive study by means of measuring the serum levels of 17 trace elements of 19 patients with primary laryngeal cancer (as cases) and of 19 patients with other diseases(as controls).Both fluorospectrophotometer analyis (to measure serum selever) and icpaes (to measure the other serum elements levels) were applied in this study.RESULTS T test in groups was used to test the significance between cases and controls and the results showed that the mean value of the case group was significantly higher than that of control group: B, Cd, Mo, P, Ti and Zn. Analysed with stepwise regression method, the data showed higher serum Cd and Zn levels were strongly associated with laryngeal cancer.CONCLUSIONS ’ It suggests that further research should be undertaken to clarify the role of these two elements in the initiation and development of laryngeal cancer.