喉癌与蛋白激酶C活性的关系

The research for the relationship between laryngeal cancer and protein kinase C

目的为了探讨喉癌与蛋白激酶C(PKC)活性的关系。方法应用Takai蛋白浓度梯度,通过同位素放射活性测定PKC活性。结果癌组织胞浆中PKC比活性(6.63±0.64pmol/mg.min)显著高于正常组织胞浆中PKC比活性(4.73±0.54pmol/mg.min)。结论提示癌组织中PKC活性升高很可能是被癌基因激活。

PURPOSE To explore the relationship between laryngeal cancer and protein kinase C (PKC).METHODS Using Takai gradient of protein concentration, we measured the activity of PKC through measuring the activity of radioscope.RESUITS The PKG activity in cellular plasma of cancer tissue (6.63+0.64pmol/ mg. min) is apparently higher than in cellular plasma of normal tissue (4.73 + 0.54pmol/mg. mol).CONCLUSIONS It indicates that the rising of PKC activity of cancer tissue may be activated by oncogene.