癌周Ⅳ型胶原分布与下咽癌侵袭性的相关研究

The related study of the distribution of CIV surrounding hypopharyngeal carcinoma and its invasion

目的研究下咽癌癌巢周围基底膜中Ⅳ型胶原的分布及其意义。方法采用Ⅳ型胶原纤维单机检测65例下咽癌。结果肿瘤分化越差,基底膜缺损越严重。结论分化程度低的下咽癌,可产生更多的下咽癌Ⅳ型胶原酶,严重破坏基底膜,侵袭性较强,其可作为恶性程度指标。

PURPOSE In order to detect the distribution of CIV surrounding hypopharyngeal carcinoma and its clinical significance.METHODS 65 cases of hypopharyngeal carcinoma slides were immunohistochemically examined using anti-CIV rnono-clonal antibody.RESULTS Heavily defective basement membrane(BM)was much more frequendy observed in cases poor histologic differentiation.CONCLUSIONS The poorly differentiated hypopharyngeal carcinoma secrete more type IV collagenase,and those are greater destruction of basement membrane(BM)and more apparent invasion,which may be helpful to determine the malignant extent of hypopharyngeal carcinoma.