硝苯吡啶预防眼科新福林散瞳的心血管副反应

Prevention with nifedipine of adverse cardiovascular effects following phenylephrine mydriasis in eye surgery

目的:观察硝苯吡啶对眼科手术中局部应用新福林散瞳致血压升高的预防作用。方法:50例老年白内障合并Ⅰ期高血压病人,随机分为硝苯吡啶组(A组,25例)与对照组(B组,25例)。除A组术前40分钟舌下含化硝苯吡啶10mg,其它用药两组相同。观察术中血压、心率变化。结果:球结膜下注射新福林后B组收缩压(SBP)、舒张压(DBP)均明显上升,分别上升22.53%±13.96%,15.71±13.07(P<0.01),心率(HR)明显下降;A组SBP、DBP和HR均无明显变化(P>0.05)。结论:硝苯吡啶能有效预防Ⅰ期高血压患者采用新福林散瞳后的心血管副反应。

Purpose:To observe the hypertention - prevention effects of nifedipine following phenylephrine mydriasis in eye surgery.Method:Fifty elderly cataract patients with stage I hypertension,were randomly divided into two groups; nifedipine group and control group(The numbers of patients of the two groups were equal).Sublingual pre-rnedication with nifedipine 10mg taken 40min before surgery in nifedipine group was the only difference in treatment between group A and group B.Blood pressure(BP)and heart rate(HR)were monitored.Result:Both SBP and DBF increased obviously(P&lt;0.01)after subcon-junctive injection of phenylephrine in control group.SBP amd DBP increased 22.53%±13.96% and 15.71%±13.07% respectively.However,HR decreased obviously.There were no significant changes in SBP,DBP and HR in nifedipine group.Conclusion:nifedipine can prevent hypertention following phenylephrine mydriasis effectively in patients with stage I hypertension.