喉癌与喉咽癌患者E-选择素含量及意义

Content and significance of SE - SLT in patients with laryngeal cancer and laryngopharynx cancer

目的通过检测喉癌及喉咽癌患者血浆SE-SLT的含量来探讨它的临床意义。方法通过定量ELISA法,检测了19例正常人及35例喉癌及喉咽癌患者,和其中15例术后患者的血浆SE—SLT的含量。结果 19例正常对照组及35例喉癌及喉咽癌组或SE—SLT含量分别是29.82±4.88(μg/L),及49.66±8.16(μg/L);Ⅰ和Ⅱ期组及Ⅲ和Ⅳ期组的SE—SLT含量分别是42.50±6.10(μg/L),54.11±6.20(μg/L);15例术前组及其术后组分别是45.12±7.09(μg/L),38.85±6.40(μg/L)。经检验喉癌和喉咽癌组明显高于正常对照组(P<0.01),Ⅰ和Ⅱ期组明显低于Ⅲ和Ⅳ期组(P<0.01),15例术后组明显低于其相应的术前组(P<0.01)。结论喉癌和喉咽癌患者血浆SE—SLT含量与病情严重程度有关,可作为疗效观察、肿瘤转移及评估预后的参考指标。

PURPOSE To detect the content of SE - SLT in patients with largngeal cancer (LC) and laryngopharynx cancer(LPC) and discuss the significance.METHODS With quantitive ELLSA method, the plasma SE - SLT content of 19 normal control group, 35 LC and LPC group and 15 postoperative group was detected.RESULTS The SE - SLT content of 19 control group and 35 LC and LPC group was 29. 82 ± 4.88 (μg/ 1), and 49.68 ± 8.16 (μMg/1) respectively, and the SE -SLT content of group in stage Ⅰ and Ⅱ and group in stage Ⅲ and Ⅳ was 42.50± 6. 10(μg/l) , and 54.11 ±6.2 (μg/1) respectively, the SE - SLT content of 15 preoper-ative group and postoperative group was 45. 12± 7. 09 (μg/1), and 38.85 ± 6.40(μg/l). The SE - SLT content of the group with LC and LPC was significantly higher than that of the control group ( P &lt; 0.01). The SE - SLT content of the group in stage Ⅲ and Ⅳ (P &lt; 0.01) . The SE-SLT content dropped after the operation on 15 patients with LC and LPC(P &lt; 0.01).CONCLUSION The changes of the content are correlated with the patients condition, so it can be used as an index for judging the curative effects, the progression and the prognosis.