脑缺血再灌流中血压对自由基脑损害影响的实验研究

Influence of blood pressure on free redical damage during cerebral ischemia and reperfusion in rabbits

本实验通过对45只兔血和脑组织中丙二醛(MDA)和超氧化物岐化酶(SOD)含量变化及组织病理改变的观测,探讨了脑缺血再灌流时不同水平血压对自由基脑损害的影响。结果提示,正常血压组动物的脑损害较轻,略低血压组次之,高血压及超高血压组脑损害较重。因此,于脑缺血后再灌流时,将血压控制在90～130mmHg范围内,有益于减轻自由基脑损害。

The contents of Malondialdehyde(MDA) and Superoxide dismutase (SOD) were measured in the brain and blood of 45 rabbits. The epileptic seizures and pathological changes were observed to study the relationship between different levels of blood pressure and the generation of free radicals and their influence to brain damage during reperfusion. Results showed that the post-ischemic damage of brain became worse and free radicals' generation most markedly increased in moderately and extremely hyper-tensive groups, less markedly in hypotensive group, but least seriously in normo-tensive group. It is coacluded that the blood pressure should be regulated to normal level (90-130mmHg) during precedure of reperfusion after the cerebral ischemia improves, to reduce the generation of free radicals and alleviate the brain damage.