D二聚体与脑血管病关系的研究

The study of relation between D-dimer and cerebrovascular disease

目的 探讨D二聚体(DDimer,DD)与脑血管病的关系。方法 采用ELISA法,分别采取观察对象空腹静脉血2ml,脑血管病患者为发病后1周内采血,定量检测急性脑血管病及高血压、脑动脉硬化患者血浆DD含量。结果 短暂性脑缺血发作(TIA)、脑梗塞及蛛网膜下腔出血(SAH)与正常对照组相比有显著性差异(P<005),高血压、脑动脉硬化及脑出血与正常对照组相比无显著性差异(P>005),SAH血浆DD含量与各组相比有显著性差异(P>005),SAH血浆DD含量与各组相比有显著性差异(P<005),其他各组两两比较无显著性差异(P>005)。结论 测定DD对急性脑血管病的诊断有价值,对其鉴别诊断无参考意义。

Objective To inquire into the relation between D dimer and cerebrovascular disease Methods The plasma D dimer content of the patients with acute cerebrovascular diseasse,hypertension and cerebral arteriosclerosis has been measured by ELISA’s method 2ml fasting blood sample of patients was taken,in which,the blood sample of patients with acute cerebrovascular disease was taken within one week after onset of disease Results The D imer content of the patients with TIA,cerebral infarction and subarachnoid hemorrhage(SAH) were remarkably increased and as compared with normal control,there was significant difference(P&lt;0 05) But comparison between normal control and hypertension,cerebral arteriosclerosis or cerebral hemorrhage,there was not remarkable difference(P&gt;0 05) Compared with any other group,the D dimer content of SAH had remarkable increased(P&lt;0 05) Comparsion between any two groups except SAH and normal control,there was not remarkable difference(P&gt;0 05) Conclusion The measurement of D dimer in plasma is of value to diagnosis of acute cerebrovascular disease,but it is not of value to differential diagnosis