蕊木宁F对小鼠实验性肝损伤的保护作用

PROTECTIVE ACTION OF KOPSININE F AGAINST EXPERIMENTAL LIVER INJURY IN MICE

蕊木宁(kopsinine)F(K-F)系自云南蕊木提出的一种吲哚类生物碱。该成分对小鼠因注射CCl_4,硫代乙酰胺,TAA及扑热息痛引起的肝损伤有明显的保护作用,使血清谷丙转氨酶降低,肝脏病理损害减轻。该成分对CCl_4引起的肝微粒体脂质过氧化反应和^(14)CCl_4与肝微粒体进行的共价结合亦有抑制作用。此外,K-F还能提高小鼠的肝微粒体细胞色素P-450活性。以上结果提示蕊木宁F对小鼠实验性肝损害有保护作用。

Kopsinine F is an indole alkaloid. The present studies show that prior oral administration of kopsinine F 150 mg/kg significantly protected mice from liver injuries induced by intraperitoneal injection of CC14, thioacetamide and acetaminophen. The alkaloid also inhibited CCla induced lipid peroxidation （MDA, formation） of liver microsomes and 14CCl4 covalent binding to lipids of liver microsomes in vitro. In addition, kopsinine F significalty induced hepatic mierosomal cytochrome P-450 in mice. The results indicate that kopsinine F has hpatoeprotective activity in mice.