摘要
蕊木宁(kopsinine)F(K-F)系自云南蕊木提出的一种吲哚类生物碱。该成分对小鼠因注射CCl_4,硫代乙酰胺,TAA及扑热息痛引起的肝损伤有明显的保护作用,使血清谷丙转氨酶降低,肝脏病理损害减轻。该成分对CCl_4引起的肝微粒体脂质过氧化反应和^(14)CCl_4与肝微粒体进行的共价结合亦有抑制作用。此外,K-F还能提高小鼠的肝微粒体细胞色素P-450活性。以上结果提示蕊木宁F对小鼠实验性肝损害有保护作用。
Kopsinine F is an indole alkaloid. The present studies show that prior oral administration of kopsinine F 150 mg/kg significantly protected mice from liver injuries induced by intraperitoneal injection of CC14, thioacetamide and acetaminophen. The alkaloid also inhibited CCla induced lipid peroxidation (MDA, formation) of liver microsomes and <sup>14</sup>CCl<sub>4</sub> covalent binding to lipids of liver microsomes in vitro. In addition, kopsinine F significalty induced hepatic mierosomal cytochrome P-450 in mice. The results indicate that kopsinine F has hpatoeprotective activity in mice.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第3期165-169,共5页
Acta Pharmaceutica Sinica