期刊文献+

用NOE差谱和二维核磁共振技术研究3S-取代烷氧基-奎宁环烷的立体化学

~1H, ^(13)C NMR AND STEREOCHEMISTRY STUDIES OF 3SSUBSTITUTED ALKOXYLQUINUCLIDINE BY TWO-DIMENSIONAL AND NOE DIFFERENCE NMR TECHNIQUES
下载PDF
导出
摘要 用3S-奎宁环醇与环氧化合物反应,得到化合物(Ⅰ)的二个光学异构体(3S-1)和(3S-2)。它们的生物活性有明显差别。本文采用NOE差谱和二维NMR技术指定了各异构体的~1H和^(13)C信号的归属,确定了它们的溶液态构象,测定了其C-11的绝对构型,并且阐明了立体结构与生物活性间的关系。C-11绝对构型的测定结果经X-射线衍射测定进一步得以肯定。 By using optically pure 3S-quinuclidinol, two diastereoisomers(3S-1) and (3S-2) of 3-(substituted) alkoxy-quinuclidine were synthesized. <sup>1</sup>H and <sup>13</sup>C NMR spectra of (3S-1) and (3S-2) have been completely analyzed utilizing doudlequantum filtered COSY, <sup>13</sup>C-<sup>1</sup>H COSY and NOE difference experiment. The NOE difference experiment was used to determine the absolute configuration at C-11 of the diastereomers. According to the results of NOE difference and variable concentration NMR experiments, the configuration about C-11 of (3S-1) is designated as R (1A), whereas the configuration about C-11 of (3S-2) is designated as S (1B). The result was confirmed by X-ray diffraction analysis.
机构地区 军事医学科学院
出处 《药学学报》 CAS CSCD 北大核心 1989年第3期194-199,共6页 Acta Pharmaceutica Sinica
关键词 二维核磁共振 NOE差谱 抗胆碱物 非对映异构体 绝对构型 Two-dimensional NMR NOE Difference experiment Anticholinergics Diastereomer Absolute configuration
  • 相关文献

参考文献2

  • 1高建华,文广伶,张其楷.光学纯羟基醚类化合物的合成和分离[J]药学学报,1987(09).
  • 2文广伶,李叔壎,张其楷.2,2,2-苯基羟基取代基乙基(环烃胺基)醚类化合物的合成[J]军事医学科学院院刊,1985(06).

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部