放、化疗联合干扰素治疗头颈部非霍奇金淋巴瘤的临床观察

Clinic study on chemo radiotherapy unite interferon (IFN) on non-Hodgkin lymphoma of head-neck

目的探讨应用定期规则化疗、放疗并配合干扰素注射对非霍奇金氏淋巴瘤(NHL)的临床疗效、缓解率和生存、不良反应及处理措施。方法应用不同方案联合定期化疗连续三年;放疗采用CO-60γ线外照射,总量50～60GY/5～6周;干扰素在化疗的间歇期应用,每年4～6个疗程。至少坚持3～5年以上。结果本文30例患者经放、化疗后的完全缓解率(GR)为87%,配合干扰素治疗的24例目前全部存活;放、化疗的不良反应主要是白细胞降低、脱发、口腔溃疡、口咽部疼痛和消化道反应;干扰素的副作用为发热、皮疹和乏力;分别给予相应处理。结论头颈部NHL放、化疗联合干扰素的缓解率高、生存时间长、无明显的副作用。对患者的预后有重要意义。

Objective To evaluate curative effect and adverse effect of chemo radiotherapy and interferon(IFN)on non-Hodgkin lymphoma in head-neck. Methods chemotherapy differ with regimen for 3 years.a 5～6 weeks DT 50～60 GYradiotherapy (CO-60),make of use on IFNin;chemotherapy,a 4～6 period of treatmet in first year and exceed 3～5 years.Results In 30 cases CR was 87%(26/30),6 Cases died because refuse treatment (4/6) and recurrence (2/6) after CR.24survivals who received treatment for IFN. Conclusion chemo radiotherapy united NHL has better curative effect and lessside effect,It were very important for survivals.