降钙素原在小儿发热性疾病病因鉴别诊断中的作用

Value of procalcitonin in differentiate between fever diseases in children

目的探讨降钙素原在小儿发热性疾病病因鉴别诊断中的应用价值。方法回顾分析了67例发热性疾病患儿的临床资料,对3组患儿血清降钙素原(procalcitonin,PCT)与C反应蛋白(CRP)以及血常规中性粒细胞计数等传统炎性指标进行了比较分析。结果细菌性感染组的PCT阳性率及PCT≥2ng/ml例数比例均明显高于其他感染组和非感染组(P<0.01),而在其他感染组和非感染组之间进行比较,该两项指标差异均无显著意义(P>0.05)。传统炎症指标均显示细菌性感染组显著高于其他感染组(P<0.01),但细菌性感染组与非感染组的差异无显著性意义(P>0.05)。结论单独依靠PCT或传统炎症指标来判断小儿发热性疾病的病因,都有一定的局限性,但结合两类检验指标,能够满意地鉴别细菌性感染、非细菌性感染以及非感染性因素引起的发热。

Objective To evaluate the Value of procalcitonin (PCT) in differentiate between fever diseases in children. MethodsThe clinical data and the level of plasma PCT, C-reaction protein (CRP) and the examination of white blood cell of 3group patients with fever diseases, 67 cases in total, had been investigated. Results The positive rate of PCT in thegroup of bacteria infectious was significantly higher than others (P<0.01). The number of the cases with PCT≥2ng/ml in the same group was significantly more too (P<0.01). But the difference between the group of not bacteria infectiousand the group of non-infectious was not significantly(P>0.05). Conclusions Causes can be determined satisfactorilywhatever bacteria infectious or not bacteria infectious or non-infectious, if the analyses combined the level of plasma PCTand CRP and the examination of white blood cell had been done.