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前列腺癌相关基因研究 被引量：4

Review on current research of involving genes in prostate cancer
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摘要 前列腺癌是目前最重要的危害欧美国家男性健康的肿瘤疾病,在我国发病率也呈上升趋势。本文综述了前列腺相关基因研究的最新文献,分染色体畸变、易感基因、原癌基因、抑癌基因和其他基因等五个部分。 Prostate cancer is the most significant malignancy among men in the Western developed countries nowa-days.This article reviews updated literatures on specific genetic alternations reported to be operative in prostate cancer,which is divided into five parts,includes chromosomal aberrations,susceptibility genes,proto-oncogenes,tu-mor suppressor genes,and other genes.
作者 万里川 周建光 等
机构地区 军事医学科学院生物工程研究所
出处 《生物技术通讯》 CAS 2002年第5期383-388,共6页 Letters in Biotechnology
基金 国家自然科学基金项目(30070296)
关键词 前列腺癌 相关基因 染色体畸变 易感基因 雄激素受体 端粒酶 PC-1基因 prostate cancer chromosomal aberration susceptibility gene androgen receptor telomerase PC-1gene
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献30

  • 1Jussi P, Tapio V. Molecular genetics of prostate cancer[J]. Ann Med, 2001, 33:130
  • 2Bratt O. Hereditary prostate cancer[J]. BJU International, 2000,85:588
  • 3Reiter R, Sato I, Thomas G, et al. Coamplification of prostate stem cell antigen(PSCA) and MYC in locally advanced prostate cancer[J]. Genes chromosomes cancer, 2000, 27:95
  • 4Thomas S, Kerstin J, Frank B, et al. Gain in chromosome 8q correlates with early progression in hormonal treated prostate cancer[J]. European Urology, 2002,41:167
  • 5Smith J, Freije D, Carpten J, et al. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genomewide search[J]. Science, 1996, 274, 1371
  • 6Berry R, Schroeder J, French A, et al. Evidence for a prostate cancer susceptibility locus on chromosome 20 [J]. Am J Hum Genet, 2000, 67:82
  • 7Avila D, Zoppi S, McPhaul M, et al. The androgen receptor in syndromes of androgen insensitivity and in prostate cancer[J]. J Steroid Biochemistry & Molecular Biology, 2001, 76:135
  • 8Xiao Z, David F. The role of vitamin D in prostate cancer[J].Steroids, 2001, 66:293
  • 9Steven S, Ingrid J. A review of genetic polymorphisms and prostate cancer risk[J]. Ann Epidemiol, 2002, 12:182
  • 10Nam W, Andrew M. Telomerase activity modulation in the prevention of prostate cancer[J]. Urology, 2001, 57:148

同被引文献55

  • 1陈朝晖,肖传国.雄激素受体异常激活与激素非依赖性前列腺癌的形成机制[J].医学分子生物学杂志,2004,1(5):309-312. 被引量：2
  • 2张军,吕朝晖,母义明,潘长玉.前列腺癌原癌基因[J].医学综述,2006,12(12):725-727. 被引量：3
  • 3马克学,席兴字,李芬.表观遗传修饰与干细胞分化调控[J].生命的化学,2007,27(2):136-138. 被引量：1
  • 4萨姆布鲁克 弗里奇 曼尼阿蒂斯.分子克隆实验指南:第二版[M].北京: 科学出版社,1998年.852～897.
  • 5Ribeiro FRet al. Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas. Mol Cancer, 2006, 5:33.
  • 6Shen C et al. Molecular genetics of prostate cancer. Genes Dev, 2000, 14:2410-2434.
  • 7Nelson WG et al. Abnormal DNA methylation, epigenetics, and prostate cancer. Front Biosci, 2007, 12:4254-4266.
  • 8Varambally Set al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature, 2002, 419:624-629.
  • 9Van Leender GJ et al. Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. Eur Urol, 2007, 52: 455-463.
  • 10Bracken AP et al. Genome-wide mapping of polycomb target genes unravels their roles in cell fate transitions. Genes Dev, 2006, 20:1123-1136.

引证文献4

二级引证文献6

生物技术通讯
2002年 第5期

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