新生儿PON2基因多态性与早产的关系

Association of PON2 Gene Polymorphisms in Neonates with Preterm

探讨新生儿对氧磷酶2基因多态性（PON2148,PON2311）对早产的影响。采用横断面调查方法,使用统一的调查表,由安庆市各县医院对入院分娩孕妇及其单胎、活产、早产和对照新生儿进行调查,共得到有效样本194个母亲一新生儿对。单因素分析结果显示:PON2 Ala148Ala纯合子基因型与Gly148Gly纯合子基因型/Ala148Gly杂合子基因型比较致早产的危险性升高且有显著意义;同样,PON2 Ser311Ser纯合子基因型致早产的危险性升高且有显著意义。进一步分析PON2148位点多态性和PON2311位点多态性是否存在交互作用,结果显示:这两个位点多态性之间无明显交互作用。对氧磷酶2基因PON2148位点多态性和PON2311位点多态性与新生儿早产相关,但PON2148位点多态性和PON2311位点多态性之间对早产的影响无明显交互作用。

The objective is to investigate whether gene polymorphisms in the PON2 gene (PON2148 and PON2311) of neonates are associated with preterm. Using standard questionnaires, 194 singleton live born mother-neonate pairs (include preterm cases and term controls) were investigated by the trained field workers with cross-sectional survey at the hospitals in Anqing, Anhui Province,China. Epidemiological and clinical data and blood samples were obtained from 194 mother-neonate pairs. Among neonates,PON2 Alal48Ala homozygote is significantly associated with preterm,compared with Glyl48Gly homozygote / Alal48Gly heterozygote before and after adjustment con-founders and the same was true for PON2 SerSllSer homozygote. However, when PON2148 polymorphism and PON2311 polymorphism were considered jointly, no significant gene interaction between PON2148 polymorphism and PON2311 polymorphism in relation to preterm was observed. We draw a conclusion from this research that both PON2148 polymorphism and PON2311 polymorphism in neonates are significantly associated with preterm respectively. But the gene interactions between PON2148 polymorphism and PON2311 polymorphism in neonates are not significantly associated with preterm.