摘要
30多年前 ,已经发现体内胆固醇及胆汁酸在转录水平受反馈激活或反馈抑制的调节 ,其机理不清楚 .最近 ,随着孤儿受体LXR基因的克隆及其功能的研究 ,逐步认识到包括LXR在内的几种孤儿受体作为体内胆固醇及胆汁酸的感受器 ,在转录水平调节体内胆固醇及胆汁酸的代谢平衡 .这 4类孤儿受体在胆固醇及其代谢产物与自身代谢平衡之间建立了直接的联系 .综述了 4类孤儿受体的研究进展 。
The metabolism of cholesterol and bile acid is transcriptionaly regulated by classic feedforward and feedback signaling pathway.Recent research on orphan receptors,especially the liver X receptors(LXR),has provided new insights into the mechanism underlying the regulation of cholesterol and bile acid.These orphan receptors including LXR,farnesoid X receptor(FXR),liver receptor homologue-1(LRH-1) and small heterodimer partner(SHP) which serve as sensors for sterol metabolism connect oxysterol and bile acid with their metabolism homeostasis.We summarize the molecular biology of these orphan receptors,their roles in regulation cholesterol and bile acid homeostasis.
出处
《生命科学研究》
CAS
CSCD
2002年第3期189-193,共5页
Life Science Research
基金
国家自然科学基金资助项目 ( 30 0 70 35 8)
生命有机化学国家重点开放实验室研究课题
关键词
孤儿受体
胆固醇
胆汁酸
代谢调节
orphan receptor
cholesterol
bile acid
metabolism homeostasis
