一氧化碳在低氧性肺血管收缩反应中的作用

THE ROLES OF CARBON MONOXIDE ON HYPOXIC PULMONARY VASOCONSTRICTION

目的和方法 :观察外源性一氧化碳 (CO)对大鼠离体肺动脉环低氧性收缩反应 (HPV)的影响 ,并通过观察血红素氧化酶抑制剂ZnPPIX对HPV的影响 ,探讨内源性一氧化碳在HPV中的作用及机制。结果 :低氧可使苯肾上腺素 (PE)预收缩的肺动脉环出现明显的收缩反应 ,肺动脉cGMP含量下降 ;用ZnPPIX孵育后 ,低氧后的肺动脉cGMP含量增加 ,低氧性肺血管收缩反应 (HPV)受抑 ;外源性CO可明显增加肺动脉cGMP含量 ,HPV明显受抑。结论 :外源性CO及ZnPPIX可增加低氧后的肺动脉cGMP含量 ,抑制HPV 。

Aim and Methods: To study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings(PAR). Results: Hypoxia caused constriction in PAR preconstricted by PE.Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.Conclusion: ZnPPIX and exogenous carbon monoxide can inhibit HPV.The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.