胎牛肝细胞低分子抑瘤因子对肿瘤患者免疫功能的保护作用

The immunoprotect effect of low molecular weight natural tumor supressors from fetal bovine hepatocyte on tumor patients

目的 :观察胎牛肝细胞低分子抑瘤因子 (L MW- NTS)对接受化疗和放疗的肿瘤患者的免疫功能的保护作用。方法 :在放疗、化疗间隙期开始 ,给 5 4例肿瘤患者应用 L MW- NTS治疗 ,并以单克隆抗体 APAAP桥联酶标技术和免疫单向扩散法 ,分别检测这些肿瘤患者应用 L MW- NTS治疗前后 T细胞亚群、免疫球蛋白和补体等免疫指标 ,观察其变化情况 ,同时检测 2 0例正常人作为对照。结果 :接受放化疗后肿瘤患者免疫指标均低于正常人 (t=8.7893,P <0 .0 1) ,说明放疗、化疗对患者免疫功能有一定损害 ;在应用 L MW- NTS之后 ,继续进行放疗、化疗 ,其免疫指标得到一定程度的恢复。结论 :L MW-NTS对于患者在放疗、化疗过程中的免疫功能有明显的保护作用 ,减轻其免疫功能受损状态 。

Objective:To observe the immunoprotect effect of low molecular weight natural tumor suppressor(LMW-NTS) to the tumor patients after chemotherapy or radiotherapy.Methods:APAAP method and sigle radial immunodiffusion were adopted to detect T lymphocyte subsets,immunoglubulins and complements of 54 tumor patients who treated by LMW-NTS at interval after chemotherapy or radiotherapy,control group was 20 normal people.Results:The immune index of tumor patients after chemotherapy or radiotherapy were significantly lower than that of the control group (P<0.01),but when treating with LMW-NTS after chemotherapy or radiotherapy,the immune index of tumor patients had been improved in some extent.Conclusion:LMW-NTS can protect the immunocompetence of tumor patients after chemotherapy or radiotherapy from injury.