原发性高血压“勺型”与“非勺型”者的动态血压变异性特点

Ambulatory blood pressure variability (ABPV) character in "dippers" and "non-dippers" in patients with primary hypertension

目的 :探讨原发性高血压“勺型”与“非勺型”患者的动态血压变异性特点及临床意义。方法 :88例原发性高血压病患者分为两组 ,“勺型”组 5 4例 ,“非勺型”组 34例 ,42例正常个体为对照组。对三组的血压均值和血压变异性进行分析和比较。结果 :高血压组的 d- SBP、 d- DBP、 n- SBP、 n- DBP、 2 4h- SBP、 2 4- DBP、均高于对照组 ,“勺型”组与“非勺型”组的 2 4h- SBP、 2 4- DBP、 d- SBP无显著差异 ,而夜间血压和日间舒张压有明显差异。“勺型”组的 2 4- ABPVd低于对照组 ,“非勺型”组的 2 4- ABPVs、 2 4- ABPVd、 n- ABPVd低于“勺型”组及对照组。结论 :ABPV可能与某些靶器官 (心、肾 )损害有关 ,原发性高血压的 ABPV差异 ,也为高血压病的个体化治疗提供了客观依据。

Objective:To study ABPV character and clinical significance in 'dippers' and 'non-dippers' in patients with primary hypertension.Methods:88 patients with primary hypertension were divided into two groups.54 patients were 'dippers',34 patients were 'non-dippers'.42 normal subjects were enrolled as controlled group.The blood pressure mean value and blood pressure variability of these three groups were analysed and compared.Results:The d-SBP,d-DBP,n-SBP,n-DBP,24h-SBP,24h-DBP in hypertension group were higher than that in controlled group.No significant difference between the 'dippers' group and 'non-dippers' group was found in 24h-SBP,24h-DBP,d-SBP.But difference between the 'dippers' group and 'non-dippers' group were found in n-SBP,n-DBP,d-DBP.The 24-ABPVd in 'dippers' group were lower than that in controlled group.The 24-ABPVs,24-ABPVd,n-ABPVd in 'non-dippers' group were lower than that in 'dippers' group and controlled group.Conclusion:ABPV is associated with a higher percentage of targeted organ (heart,kidney) damage.The difference of ABPV in primary hypertension can provide the data needed for treatment of hypertension.