颌骨骨纤维异常增殖症雌激素免疫组化研究

AN IMMUNOHISTOCHEMICAL STUDY ON SEX HORMONES IN FIBROUS DYSPLASIA OF THE JAWS

目的 探讨颌骨骨纤维异常增殖症的发病机制以及年轻患者在行部分切除术后继续生长的因素 ,并为手术时机的选择提供客观依据。方法 采用免疫组化ABC法 ,用雌二醇抗体对颌骨骨纤维异常增殖症病变组织33份 ,正常人牙槽骨 1 2份进行研究。结果 病变组织有 2 1 / 33(63 .6 % )雌二醇抗体染色阳性 ,对照组无 1例阳性 ,两者间有显著差异。病变组中 2 0岁以下者 2 0 / 2 0 (1 0 0 % )阳性 ,而 2 0岁以上组仅 1例阳性 ,两者也有显著差异。结论 颌骨骨纤维异常增殖症的发生与病变组织内含有雌二醇有关 ;年轻患者在行部分切除术后继续生长也与病变组织内含有雌二醇有关 ;手术时机最好选择在 2

Objective To provide objective basis for the option of operating opportunity. Methods With the method of immunohistochemistry, 33 of fibrous dysplasia of jaws and 12 cases of normal human alveolar bone were studied, using estradiol antibody. Results 21 cases in pathological group showed estradiol antibody positive staining while none in the control group, the difference is significant, In pathological group, the 20 patients younger than 20 years all showed positive staining (100%), while only 1 case among those older than 20 years showed positive staining. There's also significant difference between them. Conclusion The occurrence of the fibrous dysplasia of jaws is related to the level of estradiol in the lesion tissue. The constant growth after ablation in puberal patients is also related to the level of estradiol in the lesion tissue. It is optimal that the operation is done when the age is after 20 years or estradiol in the lesion tissue is negative.