子宫肌瘤中孕激素受体/雌激素受体在月经周期中的变化

Changes in ratio of estrogen and progesterone receptor in uterine myomatous in the menstrual cycle

目的:研究子宫肌瘤中孕激素受体/雌激素受体在月经周期中的改变,探讨子宫肌瘤的生长与雌、孕激素受体的关系,为临床上药物治疗子宫肌瘤提供进一步的理论依据。方法:采用免疫组化方法,检测42例子宫肌瘤患者的肌瘤组织和正常肌组织中雌、孕激素受体的表达情况,通过积分的方式计算两者比值。结果:子宫肌瘤组织中雌、孕激素受体阳性率明显高于正常肌组织,两组之间有显著差异(P<0.05);肌瘤组PR/ER在子宫内膜增殖期与分泌期均低于肌组织,分泌期肌瘤组与正常组PR/ER分别高于增殖期(P<0.05)。结论:子宫肌瘤的生长,雌激素及雌激素受体在月经周期中都起着重要作用;孕激素及孕激素受体同样起着一定的作用,且以月经后半期为主。

Objective: To study the changes in ratio of estrogen (ER) and progesterone (PR) receptor in uterine myomatous in the menstrual cycle, and explore the relationship between growth of uterine myomatous and estrogen and/or progesterone receptor to provide further theory evidence for its clinical drug therapy. Methods: With immunohistochemistry method, estrogen and/or progesterone receptor expression in the tissue of 42 patients' uterine myomatous and normal controls, the ratio of two receptors was caluculated by integral means. Results: The positive rate of estrogen and progesterone receptor in the myomatous tissue were higher than that of normal control, there was significant difference between two groups (P<0. 05) . PR/ER ratio in the endometrium proliferation and secretion stage of myomatous group were lower than that of normal control, PR/ER ratio in secretion stage of myomatous group and normal control were higher than that in proliferation stage (P<0. 05).Conclusion: The growth of uterine myomatous, ER and PR play the important role in the mentrual cycle. ER and PR mainly play definite role in last half stage of menstrual cycle.