妊高征患者生化指标的变化

Changes of biochemical indexes in women with pregnancy-induced hypertension

目的:通过对妊娠高血压综合征(妊高征)患者及正常妊娠、非妊娠妇女血钙、BUN、Cr、UA、ALB、GLB、ALT、AST、ALP等生化指标的比较,探讨他们之间的相关性。方法:采用生化分析方法检测162例妊高征患者及60例正常妊娠妇女.80例非妊娠妇女的各项生化指标,并进行对照。结果:妊高征患者血钙水平明显下降,与正常妊娠、非妊娠组比较,差异显著(P<0.01),且下降的程度反映病情严重程度,均有显著性差异(P<0.01);肝功能方面妊高征组ALT、AST、ALP均高于正常妊娠组,ALB则降低,两者比较有显著性差异(P<0.01);肾功能方面BUN、Cr、UA妊高征组明显增高,有显著性差异(P<0.01),且其升高程度反映妊高征病情的严重程度(P<0.01)。结论:低血钙是妊高征的相关因素之一。妊高征患者肝肾功能皆有一定的损害,肾功能各项生化指标的变化要比肝功能敏感,且有明显相关性,其变化程度反映妊高征患者肝肾功能损害程度。

By comparing serum calcium, BUN, Cr, UA, ALB, GLB, ALT, AST and ALP between women with PIH and normal pregnant women and normal women to explore the correlation among them. Methods: The biochemical indexes of 162 women with PIH and 60 women with normal pregnancy and 80 women without pregnancy were determined with biochemistry analysis and compared. Results: Serum calcium level in women with PIH decreased significantly (P<0. 01); hepatic function of women with PIH ALT. AST and ALP were higher than those in normal pregnant women, but ALB was lower, there was significant difference between both groups (P<0. 01) . Renal function of women with PIH BUN, Cr and UA level increased. There was significant difference (P<0.01), which indicated the severity of PIH (P<0. 01). Conclusion: Low serum calcium is one of related factors of PIH, there were damage in liver and kidney function of women with PIH. Indexes for kidney function were more susceptible than those for liver function. There was obvious relation. Their changes can indicate the degree of renal and liver function damage in women with PIH.