肿瘤患者伴发抑郁焦虑症状的临床特征及其药物治疗

THE CLINICAL CHARACTERISTICS AND DRUG THERAPY FOR CANCER PATIENTS WITH ANXIETY AND DEPRESSION

目的 分析肿瘤患者抑郁焦虑的症状学特征及SSRI类药物治疗的疗效并与心血管疾病伴发的抑郁焦虑患者进行对照。 方法 研究对象采用SAS、SDS自评法及HAMA、HAMD他评法测评,用药方法:每日口服赛乐特10～20mg,共6周。 结果 肿瘤患者抑郁焦虑的发生率分别为468%和413%,其发生率及严重程度均明显高于对照组。赛乐特治疗肿瘤患者伴发抑郁焦虑症状的有效率分别为658%和711%,抑郁焦虑的变化情况以第2周、第4周最为显著,第6周则趋于平缓。 结论 肿瘤患者抑郁焦虑症状的发生率较高,症状严重,影响患者的生存质量。

PURPOSE To analyze the clinical characteristics of these patients and to evaluate the efficacy of SSRI(eg.paroxetine) in the treatment of anxiety and depression.METHODS Forty eight patients were assessed with SAS,SDS,HAMA,and HAMD rating scales and were given oral paroxetine 10～20?mg per day for six weeks,compared with the patients with cardiovascular disease who had similar symptomatology.RESULTS The incidence of anxiety and depression were 41.3% and 46.8%,respectively before treatment,the in cidence and the severity were higher than those of the control group.The efficacy of paroxetine treatment for anxiety and depression were 71.1% and 65.8%,respectively,and distinct improvements were seen mainly on the 2nd and the 4th week after the therapy.No further improvements were seen beyond the 4th week.CONCLUSIONS The incidence of anxiety and depression in cancer patients is higher and the symptoms more severe,which may influence patients quality of life and prognosis of the diease.Paroxetine treatment is safe and effective.