荧光偏振免疫分析法测定新生儿丁胺卡那霉素血药浓度及药物动力学研究

study on pharmacokinetics of Amikacin in newborns

本文用荧光偏振免疫分析法(Fluorescence Polarization Immunoassay,简称FPIA)测定20例新生儿患者丁胺卡那霉素(Amikacin 下称AMK)血清浓度。剂量按7.5mg/kg 静脉滴注给药,30min 滴毕,经时采样测得数据,用3P87程序处理数据,经分析符合一室模型,并取得药动学参数。平均Vd:0.75±S0.20_1(L/kg)Ke:0.17±0·06(h^(-1))T_(1/2):4.8±S1.8(h)C1:1.9±0.5(ml/min·kg)

Amikacin were given by constant infusion for 30 min with a dose of 7.5mg/kg to 20 newborns.The serumconcentration of Amikacin was deterroined by fluorescence polarization immunoassay.The curve of concentrationversus time fitted well to an one—compartment model using 3p87 program.The parmeters obtained were as fol-lows:Vd=0.75±0.20L/Kg;Ke=0.17±0.06h-1;t1/2=4.8±1.8h and Cl=1.9±0.5ml/min.kg