安定灌肠剂的试制及其稳定性试验

Preparation of diazepam eneama and experiment on its stability

为适合儿童用药,选用聚乙二醇-400和丙二醇为混合溶媒制备安定灌肠剂。用初均速法测定其稳定性,得到活化能为25.54kcal·mol^(-1),20℃贮存期为480d。

Polyethylene glycol（PEG-400）and propylene glycol（PG）was selected as a mixed solvent to Prepare di-azepam eneama for children use.The initial average rate method was applied to determine the stability of diazepameneama.The activationenergy was 25.54 Kcal.mol-1;the shelflife estimated at 20℃ was 480 days.