erbB家族在肝细胞癌中的表达及临床意义

The Expression and Clinical Significance of erbB family in Hepatocellular Carcinoma

目的:探讨erbB家族在肝细胞癌(HCC)组织中的表达及其意义。方法:采用免疫组化SP法检测55例HCC患者癌组织及癌旁组织中erbB家族中表皮生长因子受体(EGFR)、C-erbB-2、C-erbB-3、C-erbB-4的表达情况。结果:55例HCC患者癌组织及癌旁组织中,EGFR阳性表达率分别为58.18%(32/55)和36.36%(20/55),两者差异有显著性(P<0.05);C-erbB-4阳性表达率分别为47.27%(26/55)和72.73%(40/55),两者差异有显著性(P<0.05);而C-erbB-2、C-erbB-3在癌组织及癌旁组织中阳性表达率差异无显著性(P>0.05)。EGFR在HCC组织中的阳性表达率与临床分期、门静脉癌栓、肝外转移、术后复发等有关,C-erbB-2、C-erbB-3、C-erbB-4阳性表达率与各临床病理参数无关。结论:EGFR与肝癌的发生、发展有关,可作为HCC预后不良的参考指标;C-erbB-2及C-erbB-3可能与肝癌的发生、发展无关,而C-erbB-4低表达可能与HCC的发生有关。

Objective: In order to explore the expression and significance of the erbB family, the epidermal growth factor receptor (EGFR), C-erbB-2, C-erbB-3 and C-erbB-4 in human hepatocellular carcinoma(HCC) tissues. Methods: Immunohisto-chemistry was employed to determine the expression of erbB family in 55 cases of HCC and their adjacent liver tissues. Results: The positive rate of EGFR in the HCC tissues (58.18%, 32/55) was markedly higher than that in the adjacent liver tissues (36.36%, 20/55)(P<0.05). The positive rate of C-erbB-4, was significantly lower in the HCC tissues (47.27%, 26/55) than that of in the adjacent liver tissues (72.73%, 40/55) (P<0.05). However, no significant differences of positive rates of C-erbB-2 and C-erbB-3 in HCC tissues were observed (P>0.05) compared with their corresponding liver tissues, respectively. The expression of EGFR in the HCC tissues was significantly correlated with the clinical stage, the portal vein tumor thrombus, the presence of extrahepatic metastasis, and the recurrence of tumor; the expression of C-erbB-2? C-erbB-3 and C-erbB-4 were not correlated with the clinicopathological parameters. Conclusions: The results suggest that EGFR relates to the initiation and development of HCC. EGFR can be considered as predictive markers for treatment of HCC; C-erbB-2 and C-erbB-3 may not be involved in the initiation and progression of HCC, but the lower expression of c-erbB-4 may be relate to the initiation of HCC.