肿瘤坏死因子在缺血性卒中病人血清中的变化

The change of serum tumor necrosis factor-a in the patients with is chemic stroke

目的 探讨血清肿瘤坏死因子(TNF-α)与各类型脑梗死的关系及其对预后的影响。方法 采用ELISA法检测52例脑梗死病人血清TNF-α的含量。结果 脑梗死组明显高于正常对照组(P<0.001),而脑梗死急性期又较恢复期明显增高(P<0.01),大小梗死组之间也有明显差异(P<0.05)。但单梗死组与多梗死组之间则无明显差异(P>0.05)。结论 TNF-α参与了脑梗死的急性病理过程,监测TNF-α有助于临床上对脑梗死病人病情、治疗及预后的判断。

Objective To study the relation ship between the serum tumor necrosis factor-a(TNF-a) and various kinds of cerebral infarction,as well as its influence on the prognosis. Methods TNF-a levels were inspected with enzyme-linked immunosorbent assay(ELISA) in 52 patients with cerebral infarction. Results The TNF-a level in the patients with cerebral infarction was much higher than those in the controls(P&lt; 0.001). Moreover,in the cerebral infarction group.it was higher in acute stage than those in convalescent peri-od(P&lt;0.01). There was signficant difference between extensive infarction group and small infarction group (P&lt; 0.05). But there was no significant difference between multi- infarction group and mono-infarction group (P&gt;0.05).Conclusion TNF-a takes part in acute pathological process of cerebral infarction. It is useful for clinical judgement of the state of illness,treatment and prognosis of the patients with cerebral infarction.